Prevent using promethazine HCl and codeine phosphate oral Answer in adolescents twelve to eighteen decades of age who produce other threat elements that will enhance their sensitivity for the respiratory depressant outcomes of codeine.

5.21 Drug/Laboratory Examination Interactions Because opioid agonists might boost biliary tract strain, with resultant rise in plasma amylase or lipase concentrations, resolve of such enzyme concentrations might be unreliable for 24 hrs after administration of a dose of promethazine HCl and codeine phosphate oral Option.

That didn’t stop the use and abuse of cocaine, nevertheless. It gained its maximum recognition in the nineteen eighties as a party drug and a means to get a lot more Vitality. It was often known as a “wealthy guy’s drug” since it was pricey to keep up a cocaine habit.

Accidental Ingestion: Accidental ingestion of even 1 dose, Particularly by kids, may end up in a deadly overdose of codeine.

Cocaine is a robust neuro-stimulant drug that is definitely applied for a leisure drug. It’s a white powder in kind and it may be snorted, smoked, or dissolved and injected intravenously.

Observational experiments have shown that concomitant use of opioid analgesics and benzodiazepines increases the risk of drug-related get more info mortality compared to usage of opioids by yourself.

Children Postmarketing instances of respiratory melancholy, like fatalities, are described with utilization of promethazine in pediatric clients. Concomitant administration with other respiratory depressants may well increase the chance of respiratory melancholy.

Acute or intense bronchial bronchial asthma, in an unmonitored setting or during the absence of resuscitative machines

Usage of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with promethazine HCl and codeine phosphate oral Resolution involves very careful thing to consider of the consequences over the parent drug, codeine, as well as the Lively metabolite, morphine.

Notify clients that a home teaspoon isn't an precise measuring system and these types of use could lead on to overdosage and severe adverse reactions [see Overdosage (10)]. For prescriptions the place a measuring unit will not be furnished, a pharmacist can offer an ideal calibrated measuring system and can provide Directions for measuring the right dose.

The usage of codeine in promethazine HCl and codeine phosphate oral Option may perhaps obscure the analysis or clinical study course of individuals with acute abdominal ailments.

Even though experiencing a hallucination, someone is more more likely to engage in dangerous behaviors, which can lead to physical hurt and even assault.

Promethazine and codeine combination is employed To alleviate cough, runny or stuffy nose, sneezing, or other symptoms attributable to allergic reactions or maybe the common cold.

The respiratory despair entails a discount during the responsiveness in the Mind stem respiratory centers to equally increases in carbon dioxide tension and also to electrical stimulation.